Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.

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Networked: 660 relevant articles (10 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	von Deimling, Andreas: 26 articles (02/2015 - 12/2008)
2.	Kato, Yukinari: 17 articles (10/2015 - 12/2009)
3.	Capper, David: 15 articles (02/2015 - 10/2009)
4.	Hartmann, Christian: 15 articles (12/2014 - 12/2008)
5.	Yan, Hai: 14 articles (01/2016 - 02/2009)
6.	Wick, Wolfgang: 14 articles (02/2015 - 10/2009)
7.	Weller, Michael: 13 articles (11/2015 - 10/2009)
8.	Reifenberger, Guido: 13 articles (12/2014 - 10/2009)
9.	Lai, Albert: 11 articles (09/2015 - 05/2011)
10.	Park, Jeen-Woo: 11 articles (08/2014 - 03/2002)

Related Diseases

1.	Glioma (Gliomas) 11/01/2011 - "Similarly, the R132H isocitrate dehydrogenase 1 IDH1 mutation, which can now be detected by use of a specific antibody, predicts better outcome in gliomas. " 08/01/2015 - "Collective tissue banking, large-scale genomic, transcriptomic and methylomic expression profiling, and discoveries such as isocitrate dehydrogenase gene mutation and the C-phosphate-G island methylation phenotype have improved glioma classification schemes. " 02/01/2015 - "Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered frequently in glioma patients and are strongly correlated with improved survival. " 02/01/2015 - "Anatomical localization of isocitrate dehydrogenase 1 mutation: a voxel-based radiographic study of 146 low-grade gliomas." 01/01/2015 - "The purpose of our study was to explore the difference between isocitrate dehydrogenase (IDH)-1/2 gene mutation-positive and -negative high-grade gliomas (HGGs) using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. "
2.	Neoplasms (Cancer) 03/30/2012 - "Here, we discuss how recent sequencing studies are identifying unexpected drivers of gliomagenesis, including mutations in isocitrate dehydrogenase 1 and the NF-κB pathway, and how genome-wide analyses are reshaping the classification schemes for tumors and enhancing prognostic value of molecular markers. " 03/01/2012 - "Pathologic diversity of glioneuronal tumor with neuropil-like islands: a histological and immunohistochemical study with a special reference to isocitrate dehydrogenase 1 (IDH1) in 5 cases." 11/15/2015 - "Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer to IDH1(R132H), a structural alteration that leads to catalysis of α-ketoglutarate to the oncometabolite D-2-hydroxyglutarate. " 11/01/2015 - "Mutations in isocitrate dehydrogenase 1/2 (IDH1/2(MT)) are drivers of a variety of myeloid neoplasms. " 10/01/2015 - "Moreover, due to the fact that mutations in the Isocitrate dehydrogenase (IDH-1 and IDH-2) genes are more frequent in our IH-CCA than in our EH-CCA samples, we suggest that the tumor subtypes have a different molecular profile. "
3.	Glioblastoma (Glioblastoma Multiforme) 12/01/2013 - "Previous studies proposed that isocitrate dehydrogenase 1 (IDH1) mutation was associated with improved survival in patients with glioblastoma, but those studies reported varying estimates and yielded inconclusive results. " 08/01/2015 - "The aim of this study was to explore the difference in high mobility group A1 (HMGA1) expression and isocitrate dehydrogenase (IDH) 1 R132H point mutation in initial and recurrent glioblastoma multiforme (GBM), and to further identify whether the expression of HMGA1 has a role in the malignant progression of GBM. " 04/01/2013 - "The purpose of this study was to distinguish pseudoprogression (PP) from early true progression in patients with glioblastoma (GBM) based on the presence of a mutation in isocitrate dehydrogenase 1 (IDH1). " 02/01/2012 - "Recent studies have shown that isocitrate dehydrogenase 1/2 (IDH1/2) mutations occur frequently in secondary glioblastoma. " 12/01/2008 - "A recent study reported on mutations in the active site of the isocitrate dehydrogenase (IDH1) gene in 12% of glioblastomas. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/01/2012 - "Persistence of mutant isocitrate dehydrogenase in patients with acute myeloid leukemia in remission." 06/01/2013 - "This study was purpose to analyze the frequency and of isocitrate dehydrogenase 2 (IDH2) gene mutation in acute myeloid leukemia (AML) and its clinic significance. " 12/01/2012 - "This study was purposed to detect the mutation of isocitrate dehydrogenase 1 (IDH-1) gene in patients with acute myeloid leukemia (AML) and to explore its clinical significance. " 08/01/2011 - "The purpose of this study was to identify point mutation of the isocitrate dehydrogenase gene (IDH1 and IDH2) in patients with acute myeloid leukemia(AML) and its clinical significance. " 07/14/2011 - "We have investigated the prognostic significance of isocitrate dehydrogenase 2 (IDH2) mutations in 1473 younger adult acute myeloid leukemia patients treated in 2 United Kingdom Medical Research Council trials. "
5.	Hearing Loss (Hearing Impairment) 11/24/2010 - "Someya et al. (2010) show that the sirtuin SIRT3 mediates the protective effects of caloric restriction on age-related hearing loss by promoting the mitochondrial antioxidant system through the regulation of isocitrate dehydrogenase 2 (Idh2)."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Biological Markers (Surrogate Marker)
3.	Cytosine
4.	Guanine
5.	temozolomide (Temodar)
6.	Histones (Histone)
7.	NADP (NADPH)
8.	alpha-hydroxyglutarate
9.	Codon (Codons)
10.	O(6)-Methylguanine-DNA Methyltransferase

Related Therapies and Procedures

1.	Caloric Restriction
2.	Radiotherapy
3.	Ovariectomy (Oophorectomy)
4.	Drug Therapy (Chemotherapy)
5.	Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)