In vivo evaluation of cisplatin-loaded superabsorbent polymer microspheres for use in chemoembolization of VX2 liver tumors.

Abstract

PURPOSE:

To investigate the pharmacokinetics and efficacy of chemoembolization with a cisplatin-loaded superabsorbent polymer (SAP) suspension in a rabbit model with transplanted liver VX2 tumors.

MATERIALS AND METHODS:

VX2 tumors were implanted into the left lobe of the liver in eight rabbits. Embolization of the proper hepatic artery was performed with cisplatin-loaded or unloaded SAP. In the cisplatin-loaded SAP group (n = 4), 5 mg of SAP (106-150 μm) loading 2.35 mg of cisplatin and 0.5 mL of ionic contrast material (ioxaglic acid 320 mgI/mL) was injected into the proper hepatic artery. In the control group (hepatic arterial infusion [HAI] + SAP; n = 4), 5 mg of SAP loading 0.5 mL of ioxaglic acid alone was injected after a bolus infusion of an equivalent amount of cisplatin. Sequential change of the plasma platinum concentration within the first 24 hours was measured. Blood sampling and histopathologic examination were performed at 1-week follow-up. Magnetic resonance (MR) images were used to calculate the growth rate of the VX2 tumor.

RESULTS:

All animals underwent successful embolization. Both total and free plasma platinum mean concentrations within the first 24 hours remained lower in the cisplatin-loaded SAP group, although without statistical significance (P > .05). The mean tumor growth rate was significantly lower in the cisplatin-loaded SAP group than the control group (20% vs 116%; P = .049). Histopathologic examination revealed coagulative necrosis to nontumorous liver parenchyma in two rabbits in the cisplatin-loaded SAP group, although no deaths occurred.

CONCLUSIONS:

These results suggested that chemoembolization with cisplatin-loaded SAP was a safe and tolerable treatment and was more effective in suppressing the tumor growth.

• Authors: Noboru Maeda, Keigo Osuga, Kouki Shimazu, Eiichi Morii, Koji Mikami, Shinichi Hori, Tetsuro Nakazawa, Hiroki Higashihara, Kaname Tomoda, Hironobu Nakamura, Noriyuki Tomiyama
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 23 Issue 3 Pg. 397-404.e1 (Mar 2012) ISSN: 1535-7732 [Electronic] United States
• PMID: 22209264 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved.

Chemical References

• Acrylic Resins
• Antineoplastic Agents
• Contrast Media
• Drug Carriers
• Polyvinyls
• acrylic acid-vinyl alcohol copolymer
• Cisplatin
• Ioxaglic Acid

Topics

• Acrylic Resins (chemistry)
• Animals
• Antineoplastic Agents (administration & dosage, blood, pharmacokinetics, toxicity)
• Chemoembolization, Therapeutic (adverse effects)
• Cisplatin (administration & dosage, blood, pharmacokinetics, toxicity)
• Contrast Media (administration & dosage)
• Drug Carriers
• Hepatic Artery
• Infusions, Intra-Arterial
• Ioxaglic Acid (administration & dosage)
• Liver Neoplasms, Experimental (blood supply, drug therapy, pathology)
• Magnetic Resonance Imaging
• Microspheres
• Polyvinyls (chemistry)
• Rabbits
• Tumor Burden (drug effects)