Abstract | PURPOSE: MATERIALS AND METHODS: A total of 75 patients (86 lesions) treated with bare metal stents were randomized into three groups: 1) combination therapy (200 mg celecoxib and 20 mg doxycycline, both twice daily), 2) celecoxib (200 mg twice daily) only, and 3) non- therapy control. Celecoxib and doxycycline were administered for 3 weeks after coronary stenting. The primary endpoint was neointimal volume obstruction by intravascular ultrasound (IVUS) at 6 months. The secondary endpoints included clinical outcomes, angiographic data, and changes in blood levels of inflammatory biomarkers. RESULTS: Follow-up IVUS revealed no significant difference in the neointimal volume obstruction among the three treatment groups. There was no difference in cardiac deaths, myocardial infarctions, target lesion revascularization or stent thrombosis among the groups. Blood levels of high-sensitivity C-reactive protein, soluble CD40 ligand, and MMP-9 varied widely 48 hours and 3 weeks after coronary stenting, however, they did not show any significant difference among the groups. CONCLUSION:
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Authors | Won Ho Kim, Young-Guk Ko, Ki Woon Kang, Jung-Sun Kim, Byung-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 53
Issue 1
Pg. 68-75
(Jan 2012)
ISSN: 1976-2437 [Electronic] Korea (South) |
PMID | 22187234
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Biomarkers
- Cyclooxygenase 2 Inhibitors
- Metals
- Pyrazoles
- Sulfonamides
- Celecoxib
- Doxycycline
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Topics |
- Aged
- Angioplasty, Balloon, Coronary
- Anti-Bacterial Agents
(therapeutic use)
- Biomarkers
(metabolism)
- Celecoxib
- Coronary Artery Disease
(immunology, metabolism, therapy)
- Cyclooxygenase 2 Inhibitors
(therapeutic use)
- Doxycycline
(therapeutic use)
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Male
- Metals
- Middle Aged
- Neointima
(drug therapy, immunology, metabolism)
- Pyrazoles
(therapeutic use)
- Stents
(adverse effects)
- Sulfonamides
(therapeutic use)
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