Association between depression and vascular disease in systemic lupus erythematosus.

Abstract

OBJECTIVE:

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with increased prevalence of cardiovascular disease (CVD) and depression. Although depression may contribute to CVD risk in population-based studies, its influence on cardiovascular morbidity in SLE has not been evaluated. We evaluated the association between depression and vascular disease in SLE.

METHODS:

A cross-sectional study was conducted from 2002-2005 in 161 women with SLE and without CVD. The primary outcome measure was a composite vascular disease marker consisting of the presence of coronary artery calcium and/or carotid artery plaque.

RESULTS:

In total, 101 women met criteria for vascular disease. In unadjusted analyses, several traditional cardiovascular risk factors, inflammatory markers, adiposity, SLE disease-related factors, and depression were associated with vascular disease. In the final multivariable model, the psychological variable depression was associated with nearly 4-fold higher odds for vascular disease (OR 3.85, 95% CI 1.37, 10.87) when adjusted for other risk factors of age, lower education level, hypertensive status, waist-hip ratio, and C-reactive protein.

CONCLUSION:

In SLE, depression is independently associated with vascular disease, along with physical factors.

• Authors: Carol M Greco, Tracy Li, Abdus Sattar, Amy H Kao, Natalya Danchenko, Daniel Edmundowicz, Kim Sutton-Tyrrell, Russell P Tracy, Lewis H Kuller, Susan Manzi
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 39 Issue 2 Pg. 262-8 (Feb 2012) ISSN: 0315-162X [Print] Canada
• PMID: 22174200 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Carotid Stenosis (epidemiology)
• Cross-Sectional Studies
• Depression (epidemiology)
• Female
• Humans
• Lupus Erythematosus, Systemic (epidemiology)
• Middle Aged
• Vascular Diseases (epidemiology)