Abstract | BACKGROUND: METHODS: Between November 2006 and December 2007, 21 morbidly obese patients receiving intra-operative liver biopsy and follow-up liver biopsy 1 year after laparoscopic Roux-en-Y gastric bypass were enrolled. NAFLD activity score ( NAS) and fibrosis stage were histologically evaluated. RESULTS: The mean body mass index fell from 43.8 ± 7.5 to 28.3 ± 4.6 kg/m(2) (P < 0.01). Biochemical improvement was found in serum levels of alanine aminotransferase (P < 0.01) and γ-glutamyltransferase (P < 0.01), but not aspartate aminotransferase (P = 0.66). Histological improvement was noted in NAS (P < 0.01) and individual components, including steatosis (P < 0.01), ballooning degeneration (P < 0.01), and lobular inflammation (P = 0.02). Pre-operatively, 4 (19.0%), 11 (52.4%), and 6 (28.6%) patients were found to have NAS >/=5, 3 or 4, and </=2, respectively. All patients had NAS </=2 after surgery. Fibrosis stage also showed significant improvement (P < 0.01). CONCLUSIONS:
Bariatric surgery can achieve a dramatic improvement of NAFLD both biochemically and histologically in morbidly obese Chinese patients.
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Authors | Chi-Ming Tai, Chih-Kun Huang, Jau-Chung Hwang, Hung Chiang, Chi-Yang Chang, Ching-Tai Lee, Ming-Lung Yu, Jaw-Town Lin |
Journal | Obesity surgery
(Obes Surg)
Vol. 22
Issue 7
Pg. 1016-21
(Jul 2012)
ISSN: 1708-0428 [Electronic] United States |
PMID | 22161114
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- gamma-Glutamyltransferase
- Alanine Transaminase
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Topics |
- Adult
- Alanine Transaminase
(blood)
- Asian People
(statistics & numerical data)
- Biomarkers
(blood)
- Biopsy
- Body Mass Index
- China
(epidemiology)
- Comorbidity
- Fatty Liver
(epidemiology, pathology)
- Female
- Gastric Bypass
(methods)
- Humans
- Laparoscopy
- Liver
(pathology)
- Liver Cirrhosis
(pathology)
- Male
- Non-alcoholic Fatty Liver Disease
- Obesity, Morbid
(epidemiology, surgery)
- Risk Factors
- Treatment Outcome
- Weight Loss
- gamma-Glutamyltransferase
(blood)
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