Abstract | BACKGROUND: RESULTS: As a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months. CONCLUSION: LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.
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Authors | Andrea Henze, Jens Raila, Caroline Kempf, Petra Reinke, Anett Sefrin, Uwe Querfeld, Florian J Schweigert |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 10
Pg. 231
(Dec 07 2011)
ISSN: 1476-511X [Electronic] England |
PMID | 22151790
(Publication Type: Journal Article)
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Chemical References |
- Apoproteins
- Lipids
- Prealbumin
- RBP4 protein, human
- Retinol-Binding Proteins, Plasma
- Vitamin A
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Topics |
- Adolescent
- Adult
- Aged
- Apoproteins
(metabolism)
- Cardiovascular Diseases
(etiology)
- Child
- Female
- Glomerular Filtration Rate
- Humans
- Kidney Transplantation
(pathology)
- Lipids
(blood)
- Living Donors
- Male
- Middle Aged
- Prealbumin
(metabolism)
- Proteinuria
- Retinol-Binding Proteins, Plasma
(metabolism)
- Risk Factors
- Vitamin A
(blood)
- Young Adult
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