Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children.

Abstract

OBJECTIVES:

Obesity is associated with increased inflammation which represents a link to atherosclerosis and cardiovascular disease. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an independent marker of inflammation and atherosclerosis risk. To assess the impact of weight loss on metabolic markers of atherosclerosis including Lp-PLA2 we examined a group of Czech non-diabetic obese/overweight children exposed to a lifestyle intervention.

PATIENTS AND METHODS:

Fourty unrelated overweight/obese non-diabetic Czech children (13.7 ± 2.1 years, average BMI at baseline 29.8 ± 2.6 kg/m2) underwent 4 weeks of lifestyle modification (reduction of energy intake to age matched optimum and supervised physical activity). Anthropometrical and biochemical variables were determined at baseline and after the intervention. Lp-PLA2 mass concentration was assessed using the ELISA kit. Wilcocson's rank test and Spearman's correlation were used for statistical analysis.

RESULTS:

A significant decrease of BMI and waist circumference was associated with significant changes of plasma lipoprotein and glycaemia levels. Mass concentration of Lp-PLA2 at the baseline was 402 ± 94 μg/ml, after the intervention 368 ± 105 μg/ml (p=0.008). Change in Lp-PLA2 was associated with triglyceride level decrease (p=0.009).

CONCLUSION:

Intensive lifestyle modification leading to body weight decrease results in significant changes of plasma lipoprotein levels and, also, a drop of Lp-PLA2 levels in paediatric obese patients. However, even after the intervention Lp-PLA2 concentrations in this patient group remain elevated suggesting possible increased atherosclerosis risk in later life.

• Authors: Eva Motykova, Lukáš Zlatohlavek, Martina Prusikova, Vera Lanska, Richard Ceska, Ludmila Vasickova, Michal Vrablik
• Journal: Neuro endocrinology letters (Neuro Endocrinol Lett) Vol. 32 Suppl 2 Pg. 55-9 ( 2011) ISSN: 0172-780X [Print] Sweden
• PMID: 22101884 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 Neuroendocrinology Letters

Chemical References

• Lipids

Topics

• Adiposity (physiology)
• Adolescent
• Anthropometry
• Atherosclerosis (epidemiology)
• Body Mass Index
• Body Weight (physiology)
• Cardiovascular Diseases (epidemiology)
• Child
• Energy Intake
• Female
• Humans
• Life Style
• Lipids (blood)
• Male
• Metabolic Diseases (epidemiology)
• Obesity (rehabilitation)
• Overweight (rehabilitation)
• Risk Factors
• Waist Circumference (physiology)
• Weight Loss (physiology)