Association of CISH -292A/T genetic variant with hepatitis B virus infection.

Abstract

Cytokine-inducible SRC homology 2 domain protein (CISH) is a suppressor of cytokine signaling that controls interleukin-2 signaling pathway. We investigated the single nucleotide polymorphism (SNP) -292A>T in 473 Vietnamese hepatitis B virus (HBV) carriers and 416 healthy controls. CISH variants at -292A>T were associated to HBV infection (Allelic: OR, 1.22 95% CI, 1-1.49; P = 0.04; Recessive: OR, 1.69 95% CI 1.23-2.54; P = 0.007). A gene dose effect for the risk allele -292T was observed (P = 0.04). The level of interleukin 2 and liver enzymes such as alanine transaminase, aspartate transaminase, total bilirubin, and direct bilirubin were not associated to CISH polymorphism at position -292A>T This study associated the vital role of CISH SNP -292A>T variant to hepatitis B virus infection in a Vietnamese population.

• Authors: Hoang V Tong, Nguyen L Toan, Le H Song, Peter G Kremsner, Jürgen F J Kun, Velavan Tp
• Journal: Immunogenetics (Immunogenetics) Vol. 64 Issue 4 Pg. 261-5 (Apr 2012) ISSN: 1432-1211 [Electronic] United States
• PMID: 22033525 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Suppressor of Cytokine Signaling Proteins
• cytokine inducible SH2-containing protein

Topics

• Alleles
• Asian People (genetics)
• Chi-Square Distribution
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• Hepatitis B (genetics)
• Humans
• Odds Ratio
• Polymorphism, Single Nucleotide
• Suppressor of Cytokine Signaling Proteins (genetics)
• Vietnam