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Effects of intracellular superoxide removal at acupoints with TAT-SOD on obesity.

Abstract
TAT-SOD is a recombinant protein of superoxide dismutase fused with TAT peptide. By pure accident, we discovered that topical application of TAT-SOD to acupoints could result in acupuncture-like action. This study aimed to validate the accidental discovery by investigating the effect on simple obesity of the topical application of TAT-SOD to acupoints in comparison with acupuncture. 90 subjects were divided into 3 groups for 12-week treatments. Regular hospital acupuncture treatment was given to Acupuncture Group 3 times a week. TAT-SOD Group were instructed first to locate acupoints and apply 0.1ml of 5000u SOD/ml TAT-SOD cream in an area of 1cm(2) to each of the same set of acupoints, which they then conducted at home three times daily. Placebo Group applied the vehicle cream the same manner as TAT-SOD Group. Both TAT-SOD and acupuncture treatments decreased adiposity with overall clinical effective rates of 60.0% and 76.7%, respectively. The placebo group showed no improvement. The results validate that the enzymatic removal of the intracellular superoxide at acupoints could generate acupuncture-like effects, and indicate a possibility of the new method as a simple substitute to acupuncture and an insight of superoxide modulation along meridians for acupuncture mechanism.
AuthorsJingke Guo, Yue Chen, Bin Yuan, Shutao Liu, Pingfan Rao
JournalFree radical biology & medicine (Free Radic Biol Med) Vol. 51 Issue 12 Pg. 2185-9 (Dec 15 2011) ISSN: 1873-4596 [Electronic] United States
PMID22019441 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Gene Products, tat
  • Superoxides
  • Superoxide Dismutase
Topics
  • Acupuncture
  • Acupuncture Points
  • Adult
  • Gene Products, tat (administration & dosage, metabolism)
  • Humans
  • Obesity (metabolism, therapy)
  • Reference Values
  • Superoxide Dismutase (administration & dosage, metabolism, pharmacology)
  • Superoxides (isolation & purification, metabolism)
  • Young Adult

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