Abstract | OBJECTIVE: METHODS: RESULTS: AChEI was observed to be dose-dependent. Lannea schweinfurthii (L. schweinfurthii) (Engl.) Engl. and Scadoxus puniceus (S. puniceus) (L.) Friis & I. Nordal. root extracts showed the lowest IC(50) value of 0.000 3 mg/mL for the ethyl acetate extracts while Zanthoxylum davyi (Z. davyi) (I. Verd.) P.G. Watermann had the lowest IC(50) value of 0.01 mg/mL for the methanol extracts in the AChEI assay. The roots of Piper capense (P. capense) L.f., L. schweinfurthii, Ziziphus mucronata (Z. mucronata) Willd., Z. davyi and Crinum bulbispermum (C. bulbispermum) (Burm.f.) Milne-Redh. & Schweick. showed noteworthy radical scavenging activity and good AChEI activity. CONCLUSIONS:
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Authors | E A Adewusi, V Steenkamp |
Journal | Asian Pacific journal of tropical medicine
(Asian Pac J Trop Med)
Vol. 4
Issue 10
Pg. 829-35
(Oct 2011)
ISSN: 2352-4146 [Electronic] India |
PMID | 22014742
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Acetates
- Benzothiazoles
- Biphenyl Compounds
- Cholinesterase Inhibitors
- Flavonoids
- Flavonols
- Free Radicals
- Phenols
- Picrates
- Plant Extracts
- Reactive Oxygen Species
- Solvents
- Sulfonic Acids
- 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
- ethyl acetate
- 1,1-diphenyl-2-picrylhydrazyl
- Acetylcholinesterase
- Methanol
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Topics |
- Acetates
- Acetylcholinesterase
(metabolism)
- Africa, Southern
- Benzothiazoles
(antagonists & inhibitors)
- Biphenyl Compounds
(antagonists & inhibitors)
- Cholinesterase Inhibitors
(pharmacology)
- Colorimetry
- Dose-Response Relationship, Drug
- Flavonoids
(analysis)
- Flavonols
(analysis)
- Free Radicals
(antagonists & inhibitors)
- Fruit
(chemistry)
- Humans
- Inhibitory Concentration 50
- Methanol
- Phenols
(analysis)
- Picrates
(antagonists & inhibitors)
- Plant Extracts
(pharmacology)
- Plant Roots
(chemistry)
- Plants, Medicinal
- Reactive Oxygen Species
(antagonists & inhibitors)
- Solvents
- Spectrophotometry
(methods)
- Sulfonic Acids
(antagonists & inhibitors)
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