Rational polytherapy in the treatment of acute seizures and status epilepticus.

Abstract

We used a model of severe cholinergic status epilepticus (SE) to study polytherapy aimed at reversing the effects of seizure-induced loss of synaptic GABA(A) receptors and seizure-induced gain of synaptic NMDA receptors. Combinations of a benzodiazepine with ketamine and valproate, or with ketamine and brivaracetam, were more effective and less toxic than benzodiazepine monotherapy in this model of SE.

• Authors: Claude G Wasterlain, Roger Baldwin, David E Naylor, Kerry W Thompson, Lucie Suchomelova, Jerome Niquet
• Journal: Epilepsia (Epilepsia) Vol. 52 Suppl 8 Pg. 70-1 (Oct 2011) ISSN: 1528-1167 [Electronic] United States
• PMID: 21967369 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.

Chemical References

• Anticonvulsants

Topics

• Animals
• Anticonvulsants (therapeutic use)
• Disease Models, Animal
• Drug Therapy, Combination (methods)
• Humans
• Seizures (drug therapy)
• Status Epilepticus (drug therapy)