Prognostic utility of T-wave alternans in a real-world population of patients with left ventricular dysfunction: the PREVENT-SCD study.
Abstract | BACKGROUND: METHODS: RESULTS: Among 453 patients enrolled in the study, 280 (62%) were eligible for the TWA test. TWA was negative in 82 patients (29%), who accounted for 18% of the total population. The median of follow-up was 36 months. The 3-year event-free rate for the primary end point was significantly higher in TWA-negative patients (97.0%) than in TWA non-negative patients (89.5%, P = 0.037) and those ineligible for the TWA test (84.4%, P = 0.003). Multivariable analysis identified both non-negative TWA [hazard ratio (HR) 4.43; 95% confidence interval (CI) 1.02-19.2; P = 0.047) and ineligibility for the TWA test (HR 6.89; 95% CI 1.59-29.9; P = 0.010) to be independent predictors of the primary end point. CONCLUSIONS:
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Authors | Satoshi Shizuta, Kenji Ando, Masakiyo Nobuyoshi, Takanori Ikeda, Hideaki Yoshino, Shinichi Hiramatsu, Yukio Kazatani, Kohei Yamashiro, Katsunori Okajima, Teishi Kajiya, Yoshinori Kobayashi, Takao Kato, Satoki Fujii, Kazuaki Mitsudo, Koichi Inoue, Hiroshi Ito, Yoshisumi Haruna, Takahiro Doi, Yukiko Nishio, Neiko Ozasa, Kei Nishiyama, Toru Kita, Takeshi Morimoto, Takeshi Kimura, PREVENT-SCD Investigators |
Journal | Clinical research in cardiology : official journal of the German Cardiac Society
(Clin Res Cardiol)
Vol. 101
Issue 2
Pg. 89-99
(Feb 2012)
ISSN: 1861-0692 [Electronic] Germany |
PMID | 21960418
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Chi-Square Distribution
- Death, Sudden, Cardiac
(etiology, prevention & control)
- Disease-Free Survival
- Electric Countershock
- Electrocardiography
- Female
- Humans
- Japan
(epidemiology)
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multivariate Analysis
- Predictive Value of Tests
- Proportional Hazards Models
- Prospective Studies
- Registries
- Risk Assessment
- Risk Factors
- Stroke Volume
- Tachycardia, Ventricular
(diagnosis, etiology, mortality, physiopathology, therapy)
- Time Factors
- Treatment Outcome
- Ventricular Dysfunction, Left
(complications, mortality, physiopathology)
- Ventricular Fibrillation
(diagnosis, etiology, mortality, physiopathology, therapy)
- Ventricular Function, Left
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