Abstract | AIM: A double-blind randomized controlled study was conducted to compare the effect of magnesium oxide (1 g 12-h) with placebo given within an evidence-based multimodal rehabilitation programme on gastrointestinal recovery, pain, mobilization and hospital stay after open colonic resection. METHOD: RESULTS: The median times to first flatus and defaecation in the laxative and placebo groups were 18.0 vs 14.0 h and 42 vs 50 h (P > 0.15). Early intake of liquids, protein drinks and solid food, nausea and vomiting, pain, fatigue and mobilization were similar in the groups (P > 0.3). The median postoperative hospital stay was 3 days in both groups (P > 0.65). CONCLUSION:
Magnesium oxide does not enhance the recovery of gastrointestinal function within the context of an evidence-based multimodal rehabilitation programme after open colonic surgery.
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Authors | J Andersen, H Christensen, J H Pachler, M Hallin, H V Thaysen, H Kehlet |
Journal | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
(Colorectal Dis)
Vol. 14
Issue 6
Pg. 776-82
(Jun 2012)
ISSN: 1463-1318 [Electronic] England |
PMID | 21883811
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland. |
Chemical References |
- Laxatives
- Magnesium Oxide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Colon
(surgery)
- Defecation
(drug effects)
- Double-Blind Method
- Female
- Gastrointestinal Motility
(drug effects)
- Humans
- Laxatives
(administration & dosage)
- Length of Stay
- Magnesium Oxide
(administration & dosage)
- Male
- Middle Aged
- Postoperative Period
- Recovery of Function
- Statistics, Nonparametric
- Time Factors
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