A case of a giant glucagonoma with parathyroid hormone-related peptide secretion showing an inconsistent postsurgical endocrine status.

Abstract

A 53-year-old woman was admitted because of a giant pancreatic tumor. Hypercalcemia and a high serum parathyroid hormone-related peptide (PTHrP) level were observed. A hypoglycemic attack occurred during pancreatectomy, and the surgical specimen revealed a PTHrP-secreting glucagonoma. Liver metastases developed 1 and 5.5 years later, and bone metastases appeared 6 years after surgery. Her serum PTHrP concentrations remained normal after surgery, despite re-elevation of the serum glucagon concentration after recurrence. The clinical course of this case illustrates the process of development of neuroendocrine tumors secreting two or more hormones.

• Authors: Kiyokazu Shirai, Izumi Inoue, Jun Kato, Hiroki Maeda, Kosaku Moribata, Naoki Shingaki, Kazuki Ueda, Hisanobu Deguchi, Takao Maekita, Mikitaka Iguchi, Kimihiko Yanaoka, Hideyuki Tamai, Masashi Oka, Manabu Kawai, Hiroki Yamaue, Hironao Yasuoka, Yasushi Nakamura, Naoyuki Iso-O, Masao Ichinose
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 50 Issue 16 Pg. 1689-94 ( 2011) ISSN: 1349-7235 [Electronic] Japan
• PMID: 21841327 (Publication Type: Case Reports, Journal Article)

Chemical References

• Parathyroid Hormone-Related Protein
• Glucagon

Topics

• Bone Neoplasms (diagnosis, metabolism, secondary)
• Female
• Glucagon (metabolism)
• Glucagonoma (diagnosis, metabolism, surgery)
• Humans
• Liver Neoplasms (diagnosis, metabolism, secondary)
• Middle Aged
• Pancreatic Neoplasms (diagnosis, metabolism, surgery)
• Parathyroid Hormone-Related Protein (metabolism)
• Postoperative Period