Progression of pancreatitis prior to diabetes onset in WBN/Kob-Lepr(fa) rats.

Abstract

We established the WBN/Kob-Lepr(fa) rat as a new congenic strain for the fa allele of the leptin receptor gene (Lepr). Homozygous (fa/fa) WBN/Kob-Lepr(fa) rats provide a model of non-insulin-dependent diabetes, although its onset is secondary to pancreatitis. In the present study, we compared histopathological observations of pancreatitis in each genotype of this rat, to examine its suitability as a model of pancreatitis. The histopathological findings of the pancreatitis revealed intense changes dependent on age, such as hemorrhage or hemosiderin deposition. The pancreatitis in homozygous (fa/fa) WBN/Kob-Lepr(fa) rats were more severe than those of WBN/Kob rats.

• Authors: Toshio Akimoto, Misao Terada, Akira Shimizu
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 74 Issue 1 Pg. 65-70 (Jan 2012) ISSN: 1347-7439 [Electronic] Japan
• PMID: 21836382 (Publication Type: Journal Article)

Chemical References

• Blood Glucose

Topics

• Aging
• Animals
• Blood Glucose
• Diabetes Mellitus (pathology)
• Female
• Genetic Predisposition to Disease
• Male
• Obesity
• Pancreatitis (pathology)
• Rats
• Rats, Inbred Strains