Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism.

Abstract

PROBLEM:

Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder. This study was to evaluate whether insulin receptor substrate (IRS)-2 Gly1057Asp polymorphism influences chronic inflammatory parameters in Taiwanese patients with PCOS.

METHOD OF STUDY:

DNA was extracted from whole blood samples for genotyping and detection of IRS-2 Gly1057Asp polymorphism in 129 PCOS women and 109 control women. Ninety-seven PCOS women accepted metformin treatment for 3 months, and low-grade chronic inflammatory markers were assessed.

RESULTS:

The levels of IL-6 were significantly elevated in PCOS women compared with normal women. Among allelic variant of IRS-2, concentrations of IL-6 were greater in IRS-2 homozygous Asp population. Treatment with metformin significantly reduced IL-6, especially in PCOS patients with IRS-2 homozygous Asp variant.

CONCLUSION:

The results showed that IL-6 may be an early low-grade chronic inflammatory marker among PCOS patients with IRS-2 polymorphism in Taiwanese population. This pharmacologic study in IRS-2 polymorphism may provide more information for preventing long-term complications in PCOS.

• Authors: Yue-Shan Lin, Shaw-Jenq Tsai, Ming-Wei Lin, Cheng-Ta Yang, Mei-Feng Huang, Meng-Hsing Wu
• Journal: American journal of reproductive immunology (New York, N.Y. : 1989) (Am J Reprod Immunol) Vol. 66 Issue 6 Pg. 527-33 (Dec 2011) ISSN: 1600-0897 [Electronic] Denmark
• PMID: 21801267 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 John Wiley & Sons A/S.

Chemical References

• Hypoglycemic Agents
• Inflammation Mediators
• Insulin Receptor Substrate Proteins
• Interleukin-6
• Metformin

Topics

• Adolescent
• Adult
• Case-Control Studies
• Female
• Homozygote
• Humans
• Hypoglycemic Agents (therapeutic use)
• Inflammation (immunology)
• Inflammation Mediators (blood)
• Insulin Receptor Substrate Proteins (genetics)
• Interleukin-6 (blood)
• Metformin (therapeutic use)
• Middle Aged
• Polycystic Ovary Syndrome (drug therapy, epidemiology, genetics, immunology)
• Polymorphism, Genetic
• Taiwan (epidemiology)
• Treatment Outcome
• Young Adult