HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Peritrocal and intraperitoneal ropivacaine for laparoscopic cholecystectomy: a prospective, randomized, double-blind controlled trial.

AbstractBACKGROUND:
The goal of this study was to evaluate the effect of peritrocal, intraperitoneal, or combined peritrocal-intraperitoneal ropivacaine on the parietal, visceral, and shoulder tip pain after laparoscopic cholecystectomy.
METHODS:
Eighty patients were randomly assigned to four groups. Group A received peritrocal and intraperitoneal saline. Group B received peritrocal saline and intraperitoneal ropivacaine. Group C received peritrocal ropivacaine and intraperitoneal saline. Group D received peritrocal and intraperitoneal ropivacaine. The parietal, visceral, and shoulder tip pain were assessed at 2, 4, 8, 12, 24, and 48 h postoperatively using a visual analog scale (VAS). The frequency of the patient pushing the button of the PCA and fentanyl use were also recorded.
RESULTS:
In visceral pain, significantly lower VAS scores were observed in Group B from 2 to 4 h and in Group D from 2 to 8 h. In parietal pain, significantly lower VAS scores were observed in Group C from 4 to 24 h and in Group D from 2 to 12 h. In shoulder tip pain, significantly lower VAS scores were observed in Group B from 4 to 48 h and in Group D from 2 to 12 h. The fentanyl use and the frequency to push the button of the PCA were the highest in Group A and the lowest in Group D at every time point.
CONCLUSIONS:
We conclude that peritrocal infiltration of ropivacaine significantly decreases parietal pain and intraperitoneal instillation of ropivacaine significantly decreases the visceral and shoulder tip pain. Their effects are additive with respect to the total pain.
AuthorsSu Man Cha, Hyun Kang, Chong Wha Baek, Yong Hun Jung, Gill Hoi Koo, Beom Gyu Kim, Yoo Shin Choi, Seong Jae Cha, Young Joo Cha
JournalThe Journal of surgical research (J Surg Res) Vol. 175 Issue 2 Pg. 251-8 (Jun 15 2012) ISSN: 1095-8673 [Electronic] United States
PMID21658722 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Chemical References
  • Amides
  • Anesthetics, Intravenous
  • Anesthetics, Local
  • Ropivacaine
  • Fentanyl
Topics
  • Administration, Topical
  • Adult
  • Aged
  • Amides (administration & dosage, therapeutic use)
  • Anesthetics, Intravenous
  • Anesthetics, Local (administration & dosage, therapeutic use)
  • Cholecystectomy, Laparoscopic (adverse effects)
  • Double-Blind Method
  • Female
  • Fentanyl (administration & dosage, therapeutic use)
  • Humans
  • Infusions, Parenteral
  • Male
  • Middle Aged
  • Pain Measurement
  • Pain, Postoperative (etiology, prevention & control)
  • Prospective Studies
  • Ropivacaine
  • Shoulder Pain (etiology, prevention & control)
  • Treatment Outcome
  • Visceral Pain (etiology, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: