Abstract | AIM: MATERIALS AND METHODS: Seventeen patients undergoing TACE with PVA followed by surgery for HCC were analyzed. The PVA particles used in TACE were categorized into two groups in respects of particle sizes: the group I, 47-90 μm (n=8) and the group II, >90-250 μm (n=9). The histopathologic features of the resected HCC were characterized with the emphasis on the number of thrombosed vessels and minimal diameter of arterioles/capillaries containing polyvinyl alcohol particles. The clinical results after TACE were also addressed. RESULTS: Histopathologic examinations showed that the median minimal diameters of arterioles containing PVA particles were 0.035 mm in group I and 0.06 mm in group II (p=0.0078). We observed the PVA particle in the sinusoidal spaces of non-tumourous liver in only one patient. However, no sinusoidal infarction was demonstrated in either group. Mean tumour necrosis rate was 67% vs. 61% for the group I and II, respectively. CONCLUSIONS: The smaller PVA particles can reach and occlude more distal arteriolar capillaries, but rarely leak into non-tumourous hepatic sinusoidal spaces. Slightly better tumour necrosis rate after TACE can be achieved.
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Authors | Ming-Yuan Lee, Vincent P Chuang, Chao-Jung Wei, Tsung-Yen Cheng, Ming-Tsu Cherng |
Journal | European journal of radiology
(Eur J Radiol)
Vol. 81
Issue 9
Pg. 1976-9
(Sep 2012)
ISSN: 1872-7727 [Electronic] Ireland |
PMID | 21628086
(Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)
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Copyright | Crown Copyright © 2011. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
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Topics |
- Carcinoma, Hepatocellular
(pathology, therapy)
- Catheterization, Peripheral
(methods)
- Chemoembolization, Therapeutic
(instrumentation)
- Female
- Humans
- Liver Neoplasms
(pathology, therapy)
- Male
- Middle Aged
- Particle Size
- Polyvinyl Alcohol
(chemistry, therapeutic use)
- Statistics as Topic
- Treatment Outcome
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