Abstract | OBJECTIVE: METHOD: Applying gas chromatography/mass spectrometry analysis, plant sterol concentrations were measured in plasma and CSF of patients with AD (n = 67) and controls (n = 29). Age, gender, plasma-to-CSF albumin ratio, CSF Aβ(42) , CSF pTau, APOE4 genotype, and serum creatinine were applied as covariates in the statistical analysis for individual plant sterols in order to compare plasma and CSF plant sterol concentrations between patients with AD and controls. RESULTS: CONCLUSION:
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Authors | T Vanmierlo, J Popp, H Kölsch, S Friedrichs, F Jessen, B Stoffel-Wagner, T Bertsch, T Hartmann, W Maier, K von Bergmann, H Steinbusch, M Mulder, D Lütjohann |
Journal | Acta psychiatrica Scandinavica
(Acta Psychiatr Scand)
Vol. 124
Issue 3
Pg. 184-92
(Sep 2011)
ISSN: 1600-0447 [Electronic] United States |
PMID | 21585343
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Apolipoprotein E4
- Biomarkers
- Phytosterols
- tau Proteins
- Cholesterol
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Topics |
- Age Factors
- Aged
- Alzheimer Disease
(diagnosis, etiology, metabolism)
- Apolipoprotein E4
(genetics)
- Biomarkers
- Blood-Brain Barrier
(metabolism)
- Brain
(metabolism)
- Cerebrospinal Fluid
(metabolism)
- Cholesterol
(metabolism)
- Female
- Gas Chromatography-Mass Spectrometry
- Humans
- Male
- Middle Aged
- Phytosterols
(blood, cerebrospinal fluid, chemistry, pharmacokinetics)
- Predictive Value of Tests
- Risk Factors
- Sex Factors
- tau Proteins
(metabolism)
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