Anthropometric, clinical and laboratory comparison of four phenotypes of polycystic ovary syndrome based on Rotterdam criteria.

Abstract

AIM:

To compare all phenotypes of polycystic ovary syndrome (PCOS) for anthropometrical, hormonal, and metabolic differences according to Rotterdam criteria.

MATERIAL & METHODS:

Women with PCOS (Rotterdam definition; n = 127) and women without PCOS used as controls (n = 44). There were four phenotypes of PCOS: 56/127 (44.09%) of the patients were polycystic ovaries on ultrasound (PCO) + oligo or anovulation (O) + biochemical and/or clinical hyperandrogenism (HA), 29/127 (22.84%) were HA+O, 24/127 (18.90%) were PCO+O and 18/127 (14.17%) were HA+PCO. And 42/127 (33.07%) patients represented the new phenotypes (PCO+O and HA+PCO). Phenotypical, hormonal and metabolic parameters were compared between the groups.

RESULTS:

Waist-to-hip ratio, luteinizing hormone-to-follicle stimulating hormone ratio, testosterone, androstenedione, dehydroepiandrostenedione were lower in women with PCO+O and controls than the other three phenotypes. The highest score regarding hirsutismus was found in the HA+O phenotype and the lowest score in the PCO+O phenotype. Prevalence of metabolic syndrome and degree of insulin resistance in PCO+O phenotype was closer to control subjects than the other three phenotypes.

CONCLUSIONS:

Anthropometrical, hormonal, and metabolic differences suggest that PCO+O phenotype is closer to control group than the other PCOS phenotypes.

• Authors: Mehmet Yilmaz, Unal Isaoglu, Ilhan Bahri Delibas, Sedat Kadanali
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 37 Issue 8 Pg. 1020-6 (Aug 2011) ISSN: 1447-0756 [Electronic] Australia
• PMID: 21481088 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.

Chemical References

• Gonadotropins, Pituitary
• Testosterone Congeners

Topics

• Adolescent
• Adult
• Anovulation (etiology)
• Female
• Gonadotropins, Pituitary (blood)
• Humans
• Hyperandrogenism (etiology)
• Insulin Resistance
• Metabolic Syndrome (epidemiology, etiology)
• Obesity, Abdominal (epidemiology, etiology)
• Polycystic Ovary Syndrome (blood, diagnosis, pathology, physiopathology)
• Prevalence
• Prospective Studies
• Testosterone Congeners (blood)
• Turkey (epidemiology)
• Waist-Hip Ratio
• Young Adult