Single nucleotide polymorphisms and mRNA expression for melatonin MT(2) receptor in depression.

Abstract

Polymorphisms (rs 4753426 and rs 794837) and expression of the melatonin MT(2) receptor gene were evaluated in 181 patients with recurrent depressive disorder (rDD) and 149 healthy subjects of Polish origin. We found an increased risk for rDD in patients with the C allele and a decreased risk in patients with the T allele (rs4753426). Patients with the AT heterozygote (rs794837) had an increased mRNA level. The significance of the MT(2) receptor gene and the risk of rDD are suggested.

• Authors: Elżbieta Gałecka, Janusz Szemraj, Antoni Florkowski, Piotr Gałecki, Małgorzata Bieńkiewicz, Małgorzata Karbownik-Lewińska, Andrzej Lewiński
• Journal: Psychiatry research (Psychiatry Res) Vol. 189 Issue 3 Pg. 472-4 (Oct 30 2011) ISSN: 0165-1781 [Print] Ireland
• PMID: 21353709 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• RNA, Messenger
• Receptor, Melatonin, MT2

Topics

• Adult
• Depression (genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genotype
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• RNA, Messenger (metabolism)
• Receptor, Melatonin, MT2 (genetics)
• Statistics, Nonparametric