Abstract | OBJECTIVE: MATERIAL AND METHOD: The medical records with cerebral aspergillosis and cerebral candidiasis in Ramathibodi Hospital between January 1997 and December 2008 were analyzed. The criterion for the diagnosis of cerebral aspergillosis and cerebral candidiasis was the evidence of fungal elements from histopathologic section. The age, gender neurological manifestations, duration of symptom, associated underlying disease, predisposing risk factor, laboratory data, extent of systemic organ involvement and treatment outcome were analyzed. RESULTS: The present study included cerebral aspergillosis (n = 41) and candidiasis (n = 15). There were 23 male and 33 female patients. The mean and median ages at diagnosis were 39.7 and 45 years, respectively (range, 1 month to 87 years). The clinical presentations included alteration of consciousness (69.6%), fever (60.7%), weakness of the extremity (14.3%), cranial nerve palsy (12.5%), headache (12.59%) and seizure (5.4%). One third of the cases had underlying hematologic malignancy. The cerebral aspergillosis and cerebral candidiasis were associated with corticosteroids treatment in 32.1%. The frequent associated sites of fungal infection included the lungs (73.2%), alimentary tract (33.9%) and sinonasal tract (19.6%). CONCLUSION:
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Authors | Noppadol Larbcharoensub, Somphong Wongwichai, Piriyaporn Chongtrakool, Atthaporn Boongird, Asawin Noinang, Siriorn Paritpokee Watcharananan, Supoch Tunlayadechanont, Rawiphan Witoonpanich, Suchart Phudhichareonrat |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 93
Issue 12
Pg. 1443-50
(Dec 2010)
ISSN: 0125-2208 [Print] Thailand |
PMID | 21344808
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Antifungal Agents
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Topics |
- Adolescent
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Aged
- Aged, 80 and over
- Antifungal Agents
(adverse effects, therapeutic use)
- Aspergillosis
(epidemiology, microbiology, pathology, therapy)
- Aspergillus
(isolation & purification)
- Autopsy
- Brain Diseases
(epidemiology, microbiology, pathology, therapy)
- Candida
(isolation & purification)
- Candidiasis
(epidemiology, microbiology, pathology, therapy)
- Child
- Child, Preschool
- Comorbidity
- Female
- Hospitals, Public
- Humans
- Infant
- Infant, Newborn
- Male
- Middle Aged
- Retrospective Studies
- Risk Factors
- Thailand
(epidemiology)
- Treatment Outcome
- Young Adult
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