Abstract | BACKGROUND AND PURPOSE: The purpose of this study is to examine the feasibility of developing plasma predictive value biomarkers of cerebral ischemic stroke before imaging evidence is acquired. METHODS: Blood samples were obtained from 198 patients who attended our neurology department as emergencies - with symptoms of vertigo, numbness, limb weakness, etc. - within 4.5 h of symptom onset, and before imaging evidence was obtained and medical treatment. After the final diagnosis was made by MRI/DWI/MRA or CTA in the following 24-72 h, the above cases were divided into two groups: stroke group and non- stroke group according to the imaging results. The levels of baseline plasma antithrombin III (AT-III), thrombin- antithrombin III (TAT), fibrinogen, D-dimer and high-sensitivity C-reactive protein ( hsCRP) in the two groups were assayed. RESULTS: The level of the baseline AT-III in the stroke group was 118.07±26.22%, which was lower than that of the non- stroke group (283.83±38.39%). The levels of TAT, fibrinogen, hsCRP were 7.24±2.28 μg/L, 5.49±0.98 g/L, and 2.17±1.07 mg/L, respectively, which were higher than those of the non- stroke group (2.53±1.23 μg/L, 3.35±0.50 g/L, 1.82±0.67 mg/L). All the P-values were less than 0.001. The D-dimer level was 322.57±60.34 μg/L, which was slightly higher than that of the non- stroke group (305.76±49.52 μg/L), but the P-value was 0.667. The sensitivities of AT-III, TAT, fibrinogen, D-dimer and hsCRP for predicting ischemic stroke tendency were 97.37%, 96.05%, 3.29%, 7.89%, but the specificity was 93.62%, 82.61%, 100% and 100%, respectively, and all the P-values were less than 0.001. High levels of D-dimer and hsCRP were mainly seen in the few cases with severe large-vessel infarction. CONCLUSIONS: Clinical manifestations of acute focal neurological deficits were associated with plasma AT-III and fibrinogen. These tests might help the risk assessment of acute cerebral ischemic stroke and/or TIA with infarction tendency in the superacute stage before positive imaging evidence is obtained.
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Authors | Ran Meng, Zhi-Yong Li, Xunming Ji, Yuchuan Ding, Sui Meng, Xiaoying Wang |
Journal | Clinical neurology and neurosurgery
(Clin Neurol Neurosurg)
Vol. 113
Issue 5
Pg. 380-6
(Jun 2011)
ISSN: 1872-6968 [Electronic] Netherlands |
PMID | 21316837
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Fibrin Fibrinogen Degradation Products
- Fibrinolytic Agents
- fibrin fragment D
- Antithrombin III
- Fibrinogen
- C-Reactive Protein
- Thrombin
- Tissue Plasminogen Activator
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Topics |
- Adult
- Aged
- Antithrombin III
(analysis)
- Biomarkers
(blood)
- Brain Ischemia
(blood, complications, economics)
- C-Reactive Protein
(analysis)
- Costs and Cost Analysis
- Diabetes Mellitus
(blood)
- Female
- Fibrin Fibrinogen Degradation Products
(analysis)
- Fibrinogen
(analysis)
- Fibrinolytic Agents
(therapeutic use)
- Humans
- Hyperlipidemias
(blood)
- Male
- Middle Aged
- Predictive Value of Tests
- Risk Factors
- Stroke
(blood, economics, etiology)
- Thrombin
(analysis)
- Tissue Plasminogen Activator
(therapeutic use)
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