Abstract |
Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions ( SCARs). However, the strength of association was variable according to phenotypes and ethnic backgrounds. To explore genetic markers for allopurinol-induced SCARs in Koreans, we genotyped human leukocyte antigen (HLA) class I alleles of 25 cases of allopurinol-induced SCARs (20 cases of drug-induced hypersensitivity syndrome and five cases of Stevens-Johnson syndrome/toxic epidermal necrolysis) and 57 patients tolerant to allopurinol. Frequencies of B*5801 [92.0 vs. 10.5%, P(c)=2.45×10(-11), odds ratio (OR)=97.8], Cw*0302 (92.0 vs. 12.3%, P(c)=9.39×10(-11), OR=82.1), and A*3303 (88.0 vs. 26.3%, P(c)=3.31×10(-6), OR=20.5) were significantly higher in SCARs compared with tolerant controls. In contrast, A*0201 was not found in SCARs patients despite relatively high frequency in tolerant controls (29.8%). We found strong positive association of HLA-B*5801 and negative association of HLA-A*0201 with the development of allopurinol-induced SCARs in the Korean population.
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Authors | Hye-Ryun Kang, Young Koo Jee, Yon-Soo Kim, Chang Hwa Lee, Jae-Woo Jung, Sae Hoon Kim, Heung-Woo Park, Yoon-Seok Chang, In-Jin Jang, Sang-Heon Cho, Kyung-Up Min, Sang-Heon Kim, Kyung Wha Lee, Adverse Drug Reaction Research Group in Korea |
Journal | Pharmacogenetics and genomics
(Pharmacogenet Genomics)
Vol. 21
Issue 5
Pg. 303-7
(May 2011)
ISSN: 1744-6880 [Electronic] United States |
PMID | 21301380
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gout Suppressants
- Allopurinol
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Allopurinol
(adverse effects, therapeutic use)
- Asian People
(genetics)
- Female
- Genes, MHC Class I
- Genome-Wide Association Study
- Gout Suppressants
(adverse effects, therapeutic use)
- Humans
- Male
- Middle Aged
- Stevens-Johnson Syndrome
(etiology, genetics)
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