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Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans.

Abstract
Recent investigations suggest genetic susceptibility of allopurinol-induced severe cutaneous adverse reactions (SCARs). However, the strength of association was variable according to phenotypes and ethnic backgrounds. To explore genetic markers for allopurinol-induced SCARs in Koreans, we genotyped human leukocyte antigen (HLA) class I alleles of 25 cases of allopurinol-induced SCARs (20 cases of drug-induced hypersensitivity syndrome and five cases of Stevens-Johnson syndrome/toxic epidermal necrolysis) and 57 patients tolerant to allopurinol. Frequencies of B*5801 [92.0 vs. 10.5%, P(c)=2.45×10(-11), odds ratio (OR)=97.8], Cw*0302 (92.0 vs. 12.3%, P(c)=9.39×10(-11), OR=82.1), and A*3303 (88.0 vs. 26.3%, P(c)=3.31×10(-6), OR=20.5) were significantly higher in SCARs compared with tolerant controls. In contrast, A*0201 was not found in SCARs patients despite relatively high frequency in tolerant controls (29.8%). We found strong positive association of HLA-B*5801 and negative association of HLA-A*0201 with the development of allopurinol-induced SCARs in the Korean population.
AuthorsHye-Ryun Kang, Young Koo Jee, Yon-Soo Kim, Chang Hwa Lee, Jae-Woo Jung, Sae Hoon Kim, Heung-Woo Park, Yoon-Seok Chang, In-Jin Jang, Sang-Heon Cho, Kyung-Up Min, Sang-Heon Kim, Kyung Wha Lee, Adverse Drug Reaction Research Group in Korea
JournalPharmacogenetics and genomics (Pharmacogenet Genomics) Vol. 21 Issue 5 Pg. 303-7 (May 2011) ISSN: 1744-6880 [Electronic] United States
PMID21301380 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Gout Suppressants
  • Allopurinol
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Allopurinol (adverse effects, therapeutic use)
  • Asian People (genetics)
  • Female
  • Genes, MHC Class I
  • Genome-Wide Association Study
  • Gout Suppressants (adverse effects, therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Stevens-Johnson Syndrome (etiology, genetics)

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