Abstract | BACKGROUND AND AIMS: Limited data exist regarding fully-covered, self-expandable metal stents (CSEMS) with anchoring fins for the management of malignant distal biliary strictures. The aim of this study is to evaluate their safety and patency. METHODS: Over a period of 2 years, 70 patients (45 males, 66 ± 13 years) underwent endoscopic retrograde cholangiopancreatography (ERCP) with placement of a 10-mm (67 patients) or 8-mm diameter (3 patients) CSEMS for the palliation of distal malignant biliary obstruction (pancreatic [53] or other [17]). Data were collected prospectively for survival and stent patency; complications were evaluated retrospectively. RESULTS: After CSEMS placement, 17 patients proceeded to surgery, and 53 patients were deemed unresectable. Mean survival for non-surgical candidates was 180 days (range: 15-1091), and 170 days (range: 9-589) for patients who underwent surgical management. CSEMS were left in place and remained patent for a mean of 163 days (range: 15-1091) in non-surgical candidates, and a mean of 55 days (range: 5-126) in surgical candidates. Complications during placement included wire perforations (4) and proximal deployment requiring repositioning (4), one of which was complicated by a bile leak. Post-procedure complications were observed in 24 cases (34%) and included post-ERCP pancreatitis (8, with 2 of them severe), post-procedure pain (5, with 3 requiring admission), cholecystitis (3), stent occlusion (3), cholangitis (2), proximal migration (1), post- sphincterotomy bleeding (1), and sepsis leading to death (1). CONCLUSION: CSEMS appear to provide acceptable short-term patency rates; however, their limited long-term patency and high complication rate might limit their widespread use. Further long-term prospective data are required to confirm this observation.
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Authors | Mihir Bakhru, Henry C Ho, Vishal Gohil, Andrew Y Wang, Kristi Ellen, Bryan G Sauer, Vanessa M Shami, Michel Kahaleh |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 26
Issue 6
Pg. 1022-7
(Jun 2011)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 21299614
(Publication Type: Journal Article)
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Copyright | © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Chemical References |
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Topics |
- Aged
- Cholangiopancreatography, Endoscopic Retrograde
(adverse effects, instrumentation, mortality)
- Cholestasis
(etiology, mortality, therapy)
- Digestive System Neoplasms
(complications, mortality, therapy)
- Female
- Humans
- Male
- Metals
- Middle Aged
- Palliative Care
- Prosthesis Design
- Retrospective Studies
- Stents
- Survival Rate
- Time Factors
- Treatment Outcome
- Virginia
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