Antiulcer activity of the calcium antagonist propyl-methylenedioxyindene. IV. Effects on gastric lesions in rats induced by cold-restraint stress and thyrotropin-releasing hormone.

Abstract	Propyl-methylenedioxyindene (pr-MDI; 30 mg/kg, i.p.), an intracellular calcium antagonist, significantly reduced the number and size of erosions per stomach induced by cold-restraint stress by 69% and 86%, respectively. Our previous findings indicate that the antiulcer activity of pr-MDI is highly correlated with its inhibitory effect on gastric motor activity. Since central TRH is suggested as the brain mediator responsible for cold-restraint stress gastric ulcers in rats, the inhibitory action of pr-MDI was evaluated in the TRH-induced gastric lesion model. Pr-MDI (30 mg/kg) did not reduce the gastric erosions induced by intracisternal administration of 100ng RX77368, a stable thyrotropin-releasing hormone (TRH) analogue, even though it abolished the RX77368-induced stimulation of gastric emptying, gastric acidity, and acid output. Since pr-MDI (30 mg/kg, i.p.) significantly inhibited the stimulation of gastric motility by both cold-restraint stress and TRH, but only cold-restraint stress-induced gastric erosions were effectively reduced by the drug, the present findings suggest a possible dissociation between the ulcerogenic mechanisms of cold-restraint stress and intracisternal administration of TRH.
Authors	W S Wong, R G Rahwan, R L Stephens Jr
Journal	Life sciences (Life Sci) Vol. 47 Issue 16 Pg. 1483-9 ( 1990) ISSN: 0024-3205 [Print] Netherlands
PMID	2123509 (Publication Type: Journal Article)
Chemical References	Anti-Ulcer Agents Calcium Channel Blockers Indenes Thyrotropin-Releasing Hormone L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide propylmethylenedioxyindene Pyrrolidonecarboxylic Acid
Topics	Animals Anti-Ulcer Agents (therapeutic use) Calcium Channel Blockers (therapeutic use) Cold Temperature Gastric Acid (metabolism) Gastric Emptying (drug effects) Gastric Juice (drug effects) Indenes (therapeutic use) Male Pyrrolidonecarboxylic Acid (analogs & derivatives) Rats Rats, Inbred Strains Restraint, Physical Stomach Ulcer (chemically induced, drug therapy, etiology) Stress, Psychological Thyrotropin-Releasing Hormone (analogs & derivatives, pharmacology)

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