Soluble glycoprotein VI is raised in the plasma of patients with acute ischemic stroke.

Abstract

BACKGROUND AND PURPOSE:

Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding.

METHODS:

We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects.

RESULTS:

sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4. sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024).

CONCLUSIONS:

Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.

• Authors: Mohammad Al-Tamimi, Elizabeth E Gardiner, Jim Y Thom, Yang Shen, Matthew N Cooper, Graeme J Hankey, Michael C Berndt, Ross I Baker, Robert K Andrews
• Journal: Stroke (Stroke) Vol. 42 Issue 2 Pg. 498-500 (Feb 2011) ISSN: 1524-4628 [Electronic] United States
• PMID: 21193745 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Platelet Membrane Glycoproteins
• platelet membrane glycoprotein VI

Topics

• Acute Disease
• Aged
• Atherosclerosis (blood, complications, pathology)
• Biomarkers (blood)
• Brain Ischemia (blood, etiology, pathology)
• Cohort Studies
• Female
• Humans
• Male
• Platelet Membrane Glycoproteins (metabolism)
• Solubility
• Stroke (blood, etiology, pathology)