Comparing the cochlear spiral modiolar artery in type-1 and type-2 diabetes mellitus:a human temporal bone study.

Abstract

This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel x 100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.

• Authors: Shin Kariya, Sebahattin Cureoglu, Hisaki Fukushima, Norimasa Morita, Muzeyyen Y Baylan, Yukihide Maeda, Kazunori Nishizaki, Michael M Paparella
• Journal: Acta medica Okayama (Acta Med Okayama) Vol. 64 Issue 6 Pg. 375-83 (Dec 2010) ISSN: 0386-300X [Print] Japan
• PMID: 21173807 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Hypoglycemic Agents
• Insulin

Topics

• Adolescent
• Adult
• Aged
• Arteries (pathology)
• Case-Control Studies
• Child
• Cochlea (blood supply)
• Diabetes Mellitus, Type 1 (drug therapy, pathology)
• Diabetes Mellitus, Type 2 (drug therapy, pathology)
• Female
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Male
• Middle Aged
• Temporal Bone (pathology)
• Young Adult