Abstract | BACKGROUND: OBJECTIVE: METHODS: Studies for inclusion in our report were identified using MEDLINE, EMBASE, PUBMED, Cochrane Central Register of Controlled Trials, CINAHL, and reference lists of relevant articles. Studies were considered eligible for inclusion if they were randomized controlled trials (RCTs), evaluating the efficacy of BoNTA injections in pain reduction. All studies were assessed and data were abstracted independently by paired reviewers. The outcome measures were baseline and final pain scores as assessed by the patients. The internal validity of trials was assessed with the Jadad scale. Disagreements were resolved through discussions. MAIN RESULTS: Twenty-one studies were included in the systematic review and 15 of them were included in the final meta-analysis. There was a total of 706 patients in the meta-analysis, represented from trials of plantar fasciitis (n = 1), tennis elbow (n = 2), shoulder pain (n = 1), whiplash (n = 3), and myofascial pain (n = 8). Overall, there was a small to moderate pain reduction among BoNTA patients when compared to control (SMD = -0.27, 95% CI: -0.44 to -0.11). When the results were analyzed in subgroups, only tennis elbow (SMD = -0.44, 95% CI: -0.86 to -0.01) and plantar fasciitis (SMD = -1.04, 95% CI: -1.68 to -0.40) demonstrated significant pain relief. Although not in the meta-analysis, one back pain study also demonstrated positive results for BoNTA. Lastly, BoNTA was effective when used at ≥ 25 units per anatomical site or after a period ≥ 5 weeks. CONCLUSION:
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Authors | Tony Zhang, Aleem Adatia, Wasifa Zarin, Misha Moitri, Abi Vijenthira, Rong Chu, Lehana Thabane, Walter Kean |
Journal | Inflammopharmacology
(Inflammopharmacology)
Vol. 19
Issue 1
Pg. 21-34
(Feb 2011)
ISSN: 1568-5608 [Electronic] Switzerland |
PMID | 21076878
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
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Topics |
- Botulinum Toxins, Type A
(therapeutic use)
- Humans
- Musculoskeletal Diseases
(drug therapy)
- Musculoskeletal System
(drug effects)
- Pain
(drug therapy)
- Randomized Controlled Trials as Topic
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