Serology of celiac disease in gluten-sensitive ataxia or neuropathy: role of deamidated gliadin antibody.
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| Abstract |
The role and relevance of deamidated gliadin antibodies specific for celiac disease in gluten-sensitive ataxia/neuropathy is unknown. We investigated the association of celiac-specific serology with gluten-sensitive ataxia/neuropathy, in patients with and without gliadin-induced enteropathy. 51 patients with unexplained ataxia/neuropathy suspected to have gluten sensitivity were included in the study and their serum celiac-specific markers were measured. Deamidated gliadin-IgA (83% vs. 22%), deamidated gliadin-IgG (50% vs. 3%), tissue transglutaminase-IgA (78% vs. 11%), and anti-endomysial-IgA (70% vs. 0%), were significantly more positive in ataxia/neuropathy patients with celiac disease versus those without enteropathy (P<0.001). Our findings suggest that the serological profile of gluten-sensitive ataxia/neuropathy without intestinal involvement lacks the recognition of deamidated gliadin and tissue transglutaminase epitopes.
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| Authors | Shahrooz Rashtak, Shadi Rashtak, Melissa R Snyder, Sean J Pittock, Tsung-Teh Wu, Manish J Gandhi, Joseph A Murray |
| Journal | Journal of neuroimmunology (J Neuroimmunol) Vol. 230 Issue 1-2 Pg. 130-4 (Jan 2011) ISSN: 1872-8421 [Electronic] Netherlands |
| PMID | 21056914 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2010. Published by Elsevier B.V. |
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