Growth differentiation factor-15 and risk of recurrent events in patients stabilized after acute coronary syndrome: observations from PROVE IT-TIMI 22.
Abstract | OBJECTIVE: METHODS AND RESULTS:
GDF-15 is a transforming growth factor-β-related cytokine induced in response to tissue injury. GDF-15 concentration is associated with all-cause mortality in patients with acute coronary syndrome (ACS). We measured GDF-15 in 3501 patients after ACS, treated with moderate or intensive statin therapy in PROVE IT-TIMI 22. By using established cutoff points, GDF-15 (<1200, 1200-1800, and >1800 ng/L) was associated with 2-year risk of death or MI (5.7%, 8.1%, and 15.1%, respectively; P<0.001), death (P<0.001), MI (P<0.001), and congestive heart failure (P<0.001). After adjustment for age, sex, body mass index, diabetes mellitus, hypertension, smoking, MI, qualifying event, renal function, B-type natriuretic peptide, and high-sensitivity C-reactive protein, GDF-15 was associated with the risk of death or MI (adjusted hazard ratio per ln increase GDF-15, 2.1 [95% CI, 1.6 to 2.9]; P<0.001), death (P<0.001), MI (P<0.001), and congestive heart failure (P<0.001). There was no significant interaction between GDF-15 and intensive statin therapy for the risk of death or MI (P=0.24 for the interaction). CONCLUSIONS:
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Authors | Marc P Bonaca, David A Morrow, Eugene Braunwald, Christopher P Cannon, Songtao Jiang, Stephanie Breher, Marc S Sabatine, Tibor Kempf, Lars Wallentin, Kai C Wollert |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 31
Issue 1
Pg. 203-10
(Jan 2011)
ISSN: 1524-4636 [Electronic] United States |
PMID | 20966402
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- GDF15 protein, human
- Growth Differentiation Factor 15
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Natriuretic Peptide, Brain
- C-Reactive Protein
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Topics |
- Acute Coronary Syndrome
(blood, complications, mortality, therapy)
- Aged
- Angina, Unstable
(blood, etiology)
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Chi-Square Distribution
- Europe
- Female
- Growth Differentiation Factor 15
(blood)
- Heart Failure
(blood, etiology)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Myocardial Infarction
(blood, etiology)
- Natriuretic Peptide, Brain
(blood)
- Patient Discharge
- Proportional Hazards Models
- Recurrence
- Risk Assessment
- Risk Factors
- Stroke
(blood, etiology)
- Time Factors
- Treatment Outcome
- United States
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