Abstract |
Canine renal cell carcinomas (RCCs) are uncommon aggressive tumors that occur mainly in middle-aged male dogs. Their histologic classification bears no relationship with prognosis, and little information is available concerning their immunohistochemical properties. In this retrospective study, formalin-fixed, paraffin-embedded tissues from 13 canine RCCs were retrieved from the archives, classified histologically, and evaluated immunohistochemically. The dogs were 7 males and 6 females (1 spayed) of 10 different breeds, averaging 8 years in age. The tumors were classified as papillary, tubulopapillary, papillary-cystic, solid, or sarcomatoid. All 13 tumors were immunohistochemically positive for uromodulin, 12 for c-KIT, 11 for vimentin, 9 for wide-spectrum-screening cytokeratins, 7 for cytokeratins AE1/AE3 and carcinoembryonic antigen, 4 for cytokeratins CAM 5.2, and 3 for CD10. All 3 solid RCCs expressed vimentin, c-KIT, and carcinoembryonic antigen and were negative for cytokeratins. All 7 papillary and tubulopapillary tumors expressed vimentin; 6 (86%), cytokeratins; and 6 (86%), c-KIT. Both papillary-cystic RCCs were positive for cytokeratins and c-KIT and negative for vimentin. These results indicate that the different histologic types of RCC have characteristic immunohistochemical profiles and that c-KIT may be involved in the pathogenesis of canine RCC.
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Authors | R M Gil da Costa, J P Oliveira, A L Saraiva, F Seixas, F Faria, F Gärtner, M A Pires, C Lopes |
Journal | Veterinary pathology
(Vet Pathol)
Vol. 48
Issue 2
Pg. 427-32
(Mar 2011)
ISSN: 1544-2217 [Electronic] United States |
PMID | 20861495
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Proto-Oncogene Proteins c-kit
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Topics |
- Animals
- Biomarkers, Tumor
(metabolism)
- Carcinoma, Renal Cell
(classification, pathology, veterinary)
- Dog Diseases
(pathology)
- Dogs
- Female
- Immunohistochemistry
(veterinary)
- Kidney Neoplasms
(classification, pathology, veterinary)
- Male
- Proto-Oncogene Proteins c-kit
(metabolism)
- Retrospective Studies
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