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Meningoencephalitis caused by varicella-zoster virus reactivation in a child with dominant partial interferon-gamma receptor-1 deficiency.

Abstract
We describe a previously symptom-free 13-year-old boy with dominant partial interferon-γ receptor-1 deficiency and unusual varicella-zoster virus reactivation. This case supports the unsettled notion that some interferon-γ R-deficient patients are at enhanced risk for viral disease.
AuthorsJoachim Roesler, Christian Hedrich, Martin W Laass, Klaus Heyne, Angela Rösen-Wolff
JournalThe Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 30 Issue 3 Pg. 265-6 (Mar 2011) ISSN: 1532-0987 [Electronic] United States
PMID20842068 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Receptors, Interferon
Topics
  • Adolescent
  • Encephalitis, Varicella Zoster (diagnosis, virology)
  • Herpesvirus 3, Human (isolation & purification)
  • Humans
  • Immunologic Deficiency Syndromes (complications)
  • Male
  • Meningoencephalitis (diagnosis, virology)
  • Receptors, Interferon (deficiency)
  • Virus Activation
  • Interferon gamma Receptor

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