Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Diagnosis is still often delayed. It is mainly established on the basis of clinical and sonographic findings, urinary oxalate ± glycolate assessment, and DNA analysis. SUMMARY: Following specific conservative measures, the ultimate management is based on organ transplantation. Correction of the enzyme defect by liver transplantation should be planned before systemic oxalosis develops to optimize outcomes and may be either simultaneous (immunological benefit) or sequential (biochemical benefit) liver- kidney transplantation depending on disease staging, facilities, and access to deceased or living donors. Allograft and patient survival currently approaches that of transplant patients with kidney transplantation alone and with other diseases requiring combined liver- kidney transplantation. In addition, this strategy has also provided significant improvement in both quality of life and statural growth.
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Authors | Pierre Cochat, Sonia Fargue, Jérôme Harambat |
Journal | Current opinion in organ transplantation
(Curr Opin Organ Transplant)
Vol. 15
Issue 5
Pg. 590-3
(Oct 2010)
ISSN: 1531-7013 [Electronic] United States |
PMID | 20733487
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Disease Progression
- Humans
- Hyperoxaluria
(diagnosis, mortality, surgery)
- Hyperoxaluria, Primary
- Kidney Transplantation
- Liver Transplantation
- Quality of Life
- Transaminases
(deficiency)
- Transplantation, Homologous
- Treatment Outcome
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