Abstract | INTRODUCTION: In a previous prospective randomized trial, we found a once-a-day regimen of ceftriaxone and metronidazole to be an efficient, cost-effective treatment for children with perforated appendicitis. In this study, we evaluated the safety of discharging patients to complete an oral course of antibiotics. METHODS: RESULTS: One hundred two patients underwent laparoscopic appendectomy for perforated appendicitis. On presentation, there were no differences in age, weight, sex distribution, days of symptoms, maximum temperature, or leukocyte count between the 2 groups. There was no difference in the postoperative abscess rate between the two treatment groups. Discharge was possible before day 5 in 42% of the patients in the IV/PO arm. CONCLUSIONS: When patients are able to tolerate a regular diet, completing the course of antibiotics orally decreases hospitalization with no effect on the risk of postoperative abscess formation.
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Authors | Jason D Fraser, Pablo Aguayo, Charles M Leys, Scott J Keckler, Jason G Newland, Susan W Sharp, John P Murphy, Charles L Snyder, Ronald J Sharp, Walter S Andrews, George W Holcomb 3rd, Daniel J Ostlie, Shawn D St Peter |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 45
Issue 6
Pg. 1198-202
(Jun 2010)
ISSN: 1531-5037 [Electronic] United States |
PMID | 20620320
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Metronidazole
- Ceftriaxone
- Amoxicillin
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Topics |
- Administration, Oral
- Amoxicillin
(administration & dosage)
- Anti-Bacterial Agents
(administration & dosage)
- Appendectomy
(methods)
- Appendicitis
(diagnosis, drug therapy, surgery)
- Ceftriaxone
(administration & dosage)
- Child
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Humans
- Injections, Intravenous
- Laparoscopy
- Male
- Metronidazole
(administration & dosage)
- Preoperative Care
(methods)
- Prospective Studies
- Rupture, Spontaneous
- Treatment Outcome
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