Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats.

Abstract

It has been known that tissues of porpoise contain unique structured-lipids as combination of iso-valeric acid (iso-C5:0) and omega 3 polyunsaturated fatty acids (omega3 PUFAs). It is well known that omega3 PUFAs have lipid-lowering effects in animal and human studies. Although branched chain fatty acids have been interested in their unique functions, there is no data concerning the effect of iso-C5:0 on lipid metabolism. In this study we investigated the effect of structured-lipids from porpoise adipose tissue (porpoise oil) on lipid metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. For 4 weeks, rats were fed semisynthetic diets containing either 10% corn oil or 5% corn oil plus 5% porpoise oil. After feeding period, the porpoise oil diet significantly alleviated hepatic triglyceride accumulation compared with the control diet in OLETF rats. Although serum triglyceride level increased, serum level of adiponectin that can protect liver function and alleviate abnormalities of lipid and glucose metabolism increased in rats fed porpoise oil diet. In conclusion, results from the present study suggest that porpoise oil feeding prevents the development of fatty liver disease through the enhancement of lipoprotein secretion and increase of adiponectin production in obese rats.

• Authors: Bungo Shirouchi, Koji Nagao, Kenta Furuya, Toshiharu Nagai, Kenji Ichioka, Shigeru Tokairin, Yasuhiro Iida, Teruyoshi Yanagita
• Journal: Journal of oleo science (J Oleo Sci) Vol. 59 Issue 6 Pg. 299-305 ( 2010) ISSN: 1347-3352 [Electronic] Japan
• PMID: 20484835 (Publication Type: Journal Article)

Chemical References

• Adiponectin
• Fatty Acids, Omega-3
• Hemiterpenes
• Oils
• Pentanoic Acids
• Phospholipids
• Triglycerides
• isovaleric acid
• Corn Oil
• Cholesterol

Topics

• Adiponectin (blood, metabolism)
• Animals
• Cholesterol (blood, metabolism)
• Corn Oil
• Fatty Acids, Omega-3 (administration & dosage, chemistry, pharmacology)
• Fatty Liver (blood, drug therapy, metabolism, prevention & control)
• Hemiterpenes
• Male
• Obesity (blood, complications, drug therapy, metabolism)
• Oils (chemistry, pharmacology)
• Pentanoic Acids (administration & dosage, chemistry, pharmacology)
• Phospholipids (blood, metabolism)
• Porpoises
• Rats
• Rats, Inbred OLETF
• Time Factors
• Triglycerides (blood, metabolism)