[Histological complete response in a case of advanced gastric cancer treated by neo-adjuvant chemotherapy with S-1/CDDP].

Abstract

A 59-year-old male was found to have advanced gastric cancer with multiple lymph node metastasis including para-aortic lymph nodes(cT3, cN3, cM0, cH0, cP0, cStage IV). Since curative surgery was deemed not feasible, we tried neoadjuvant chemotherapy expecting downstaging of the tumor. S-1(120 mg/body)was orally administered for three weeks followed by one week rest, and CDDP(60 mg/m2)was administered on day 8. Three courses of treatment resulted in a marked shrinkage of the primary lesion and a reduction of lymph nodes. He was judged as clinical PR by RECIST, and a radical resection was considered possible. Laparotomy revealed neither ascites nor peritoneal dissemination, and he underwent total gastrectomy, splenectomy and D2+para-aortic lymph node dissection with curative intent. The histological diagnosis revealed complete disappearance of cancer cells in the primary lesion of the stomach and lymph nodes, confirming a pathological complete response. The patient has been alive for six months without recurrence.

• Authors: Noriko Oshima, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Masanori Tokunaga, Norihiko Sugisawa, Yusuke Taki, Yoko Motegi, Narikazu Boku, Keiko Sasaki, Masanori Terashima
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 4 Pg. 697-701 (Apr 2010) ISSN: 0385-0684 [Print] Japan
• PMID: 20414029 (Publication Type: Case Reports, Journal Article)

Chemical References

• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage, therapeutic use)
• Drug Combinations
• Humans
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Staging
• Oxonic Acid (administration & dosage, therapeutic use)
• Remission Induction
• Stomach Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
• Tegafur (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed