Origin of estrogen in isosexual precocious pseudopuberty due to a granulosa-theca cell tumor.

Abstract

The purpose of the present study was to quantify the rates of production and to define the mechanism(s) or origin of sex steroid hormones in a 3 1/2-year-old girl with isosexual precocious pseudopuberty caused by a granulosa-theca cell tumor of the ovary. The results suggest that the hyperestrogenism occurs principally due to the secretion of estradiol-17beta synthesized de novo by the tumor, but that the tumor in vivo was also capable of aromatizing C19 plasma precursor hormones to estrogen.

• Authors: J D Madden, P C MacDonald
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 51 Issue 2 Pg. 210-3 (Feb 1978) ISSN: 0029-7844 [Print] United States
• PMID: 202898 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Estrogens

Topics

• Child, Preschool
• Estrogens (metabolism)
• Female
• Granulosa Cell Tumor (complications, metabolism, pathology)
• Humans
• Ovarian Neoplasms (complications, metabolism, pathology)
• Puberty, Precocious (etiology, metabolism, pathology)
• Thecoma (complications, metabolism, pathology)