Chemoradiotherapy for locoregionally advanced squamous cell carcinoma of the base of tongue.

Abstract

BACKGROUND:

Our aim was to report the outcomes of base of tongue cancers treated with chemoradiotherapy.

METHODS:

Between 1990 and 2004, 127 patients with stage III or IV base of tongue cancer were treated with chemoradiotherapy on protocol. Indications included nodal involvement, T3/T4 tumors, positive margins, those patients refusing surgery, or were medically inoperable. The most common regimen was paclitaxel (100 mg/m2 on day 1), infusional 5-fluorouracil (600 mg/m2/day × 5 days), hydroxyurea (500 mg prescribed orally [PO] 2 × daily [BID]), and 1.5 Gy twice daily irradiation followed by a 9-day break without treatment.

RESULTS:

Median follow-up was 51 months. The median dose to gross tumor was 72.5 Gy (range, 40-75.5 Gy). Five-year locoregional progression-free survival, overall survival, and disease-free survival was 87.0%, 58.2%, and 46.0%, respectively.

CONCLUSION:

Concurrent chemoradiotherapy results in promising locoregional control for base of tongue cancer. As distant relapse was common, further investigation of systemic therapy with novel agents may be warranted.

• Authors: Aaron W Pederson, Daniel J Haraf, Mary-Ellyn Witt, Kerstin M Stenson, Everett E Vokes, Elizabeth A Blair, Joseph K Salama
• Journal: Head & neck (Head Neck) Vol. 32 Issue 11 Pg. 1519-27 (Nov 2010) ISSN: 1097-0347 [Electronic] United States
• PMID: 20187015 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins
• Bevacizumab
• Irinotecan
• Paclitaxel
• Cisplatin
• Leucovorin
• Fluorouracil
• Hydroxyurea
• Camptothecin

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bevacizumab
• Camptothecin (administration & dosage, analogs & derivatives)
• Carcinoma, Squamous Cell (mortality, pathology, therapy)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Disease-Free Survival
• Female
• Fluorouracil (administration & dosage)
• Humans
• Hydroxyurea (administration & dosage)
• Interferon alpha-2
• Interferon-alpha
• Irinotecan
• Leucovorin (administration & dosage)
• Male
• Middle Aged
• Neck Dissection
• Paclitaxel (administration & dosage)
• Radiotherapy Dosage
• Radiotherapy, Adjuvant
• Radiotherapy, Intensity-Modulated
• Recombinant Proteins
• Tongue Neoplasms (mortality, pathology, therapy)