Abstract | BACKGROUND: METHODS: RESULTS: Circulating levels of total and active HGF correlated well with coagulopathy severity, including DIC score, D-dimer, TAT and PAP levels. HGF positively correlated with IL-6 and absolute neutrophil count. In contrast to the cancer group, HGF levels were significantly increased in accordance with increased DIC scores in non- cancer group. Elevated circulating HGF was an independent prognostic marker in the non- cancer group, while HGF level failed to predict mortality in the cancer group. Amounts of HGF released from stimulated granulocytes were not significantly different between overt- DIC and no overt- DIC patients. HGF potentiated endotoxin-induced tissue factor expression of monocytes in vitro. CONCLUSION: These findings suggest that circulating HGF is a potential laboratory marker reflecting coagulation activity and DIC prognosis in non- cancer patients and that HGF may play a role in a vicious cycle of hypercoagulability.
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Authors | Soie Chung, Ji-Eun Kim, Ju Young Kim, Dong Soon Lee, Kyou-Sup Han, Hyun Kyung Kim |
Journal | Thrombosis research
(Thromb Res)
Vol. 125
Issue 6
Pg. e285-93
(Jun 2010)
ISSN: 1879-2472 [Electronic] United States |
PMID | 20185166
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biomarkers
- Interleukin-6
- alpha-2-Antiplasmin
- antithrombin III-protease complex
- plasmin-plasmin inhibitor complex
- Hepatocyte Growth Factor
- Antithrombin III
- Peptide Hydrolases
- Fibrinolysin
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Topics |
- Adult
- Aged
- Antithrombin III
- Biomarkers
(blood)
- Disseminated Intravascular Coagulation
(diagnosis, mortality)
- Female
- Fibrinolysin
(analysis)
- Hepatocyte Growth Factor
(blood)
- Humans
- Interleukin-6
(blood)
- Male
- Middle Aged
- Neoplasms
- Neutrophils
(pathology)
- Peptide Hydrolases
(blood)
- Prognosis
- Thrombophilia
(blood)
- alpha-2-Antiplasmin
(analysis)
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