Abstract | OBJECTIVE AND DESIGN: METHODS: Forty-five subjects were evaluated in five groups; individuals with gingivitis (group 1; n = 10), individuals with periodontitis (group 2; n = 10), individuals with gingivitis + type II diabetes (group 3; n = 10), individuals with periodontitis + type II diabetes (group 4; n = 10), and individuals without periodontal and systemic disease (group 5; n = 5). VEGF mRNA levels in gingival tissues were measured by quantitative real-time PCR using Lightcycler. RESULTS: Expression of VEGF mRNA was detected in all groups. There was no significant difference in expression levels of VEGF mRNA between groups (P > 0.05). CONCLUSIONS:
VEGF expression is probably related to both maintenance of periodontal health and periodontal tissue destruction. It can be concluded that systemic condition in type II diabetes mellitus under good metabolic control does not seem to have additional effects on gingival tissue VEGF mRNA levels in gingivitis and periodontitis patients.
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Authors | Gonca Cayir Keles, Burcu Ozkan Cetinkaya, Cafer Eroglu, S Burcak Simsek, Hakki Kahraman |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 59
Issue 7
Pg. 543-9
(Jul 2010)
ISSN: 1420-908X [Electronic] Switzerland |
PMID | 20127137
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Vascular Endothelial Growth Factor A
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Topics |
- Adult
- Aged
- Diabetes Mellitus
(metabolism, pathology)
- Gingiva
(metabolism, pathology)
- Gingivitis
(metabolism)
- Humans
- Middle Aged
- Periodontal Diseases
(metabolism, pathology)
- Periodontitis
(metabolism)
- RNA, Messenger
(metabolism)
- Vascular Endothelial Growth Factor A
(genetics, metabolism)
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