Abstract | PURPOSE: PATIENTS AND METHODS: Six patients with protracted gastrointestinal symptoms were diagnosed with EG because of histologic evidence of predominantly eosinophilic infiltrates in the gastrointestinal mucosa. Each patient was treated in an open trial for 12 months with ketotifen ( Zaditen), an antihistamine of the H1 class that is known to stabilize mast cells. RESULTS: All six patients improved clinically; four also gained weight. Total serum IgE levels decreased after 4 to 6 months of therapy. Clearing of eosinophilic infiltrates was documented in the four patients who underwent follow-up mucosal biopsies. CONCLUSION:
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Authors | I Melamed, S J Feanny, P M Sherman, C M Roifman |
Journal | The American journal of medicine
(Am J Med)
Vol. 90
Issue 3
Pg. 310-4
(Mar 1991)
ISSN: 0002-9343 [Print] United States |
PMID | 2003512
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin E
- Ketotifen
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Topics |
- Adolescent
- Adult
- Child
- Eosinophilia
(drug therapy, immunology)
- Female
- Gastroenteritis
(drug therapy, immunology)
- Humans
- Immunoglobulin E
(metabolism)
- Ketotifen
(therapeutic use)
- Male
- Prospective Studies
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