[B cells, antibody production, and allergy].

Abstract

IgE, a unique subclass of antibodies, leads to the development of allergic inflammation by eliciting mast cell activation. The molecular process of allergen specific IgE production which works for class switch recombination in B cells can be a good target for the treatment of allergic disorders. Here, we review the mechanism of IgE class switch recombination in B cells, and then introduce current topics including our findings; (1) preferable usage of IgE VH families in subjects with allergic diseases; (2) allergic march and epitope spreading; and (3) regulation of IgE synthesis by cognate interaction between B cells and mast cells in the local inflammatory sites such as nasal mucosa and skin.

• Authors: Chisei Ra, Satoshi Nunomura, Yoshimichi Okayama
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 67 Issue 11 Pg. 2071-5 (Nov 2009) ISSN: 0047-1852 [Print] Japan
• PMID: 19899518 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Immunoglobulin E

Topics

• Antibody Formation (physiology)
• B-Lymphocytes (physiology)
• Humans
• Hypersensitivity (immunology)
• Immunoglobulin E (biosynthesis)