Abstract | CONTEXT: OBJECTIVE: DESIGN: Total T and free T by equilibrium dialysis were measured using ultrasensitive assays in 344 women aged 65-98 yr enrolled in the Cardiovascular Health Study. Cross-sectional analyses were performed to examine the associations between total and free T and IR, MetSyn, and CHD. RESULTS: There was a stepwise increase in the homeostasis model assessment of insulin resistance with increasing total (P = 0.0.003) and free T (P = 0.02) level and a corresponding decrease in Quantitative Insulin Sensitivity Check Index (P < 0.001 and P = 0.002, respectively). In adjusted models, higher levels of both total and free T were strongly associated with abdominal obesity and high fasting glucose, the two MetSyn components most strongly linked to IR. After adjustment, women in the top quartile of total T levels had a 3-fold greater odds of MetSyn (odds ratio 3.15, 95% confidence interval 1.57-6.35) than those in the bottom quartile and a 3-fold greater odds of CHD (odds ratio 2.95, 95% confidence interval 1.2-7.3) than those in second quartile, whereas free T was not significantly associated with MetSyn or CHD. CONCLUSIONS: Higher levels of T are associated with IR, MetSyn, and CHD in elderly women. Whether T is a marker or mediator of cardiovascular disease in this population merits further investigation.
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Authors | Shrita M Patel, Sarah J Ratcliffe, Muredach P Reilly, Rachel Weinstein, Shalender Bhasin, Marc R Blackman, Jane A Cauley, Kim Sutton-Tyrrell, John Robbins, Linda P Fried, Anne R Cappola |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 12
Pg. 4776-84
(Dec 2009)
ISSN: 1945-7197 [Electronic] United States |
PMID | 19846742
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Insulin
- Testosterone
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Topics |
- Aged
- Aged, 80 and over
- Blood Glucose
(metabolism)
- Cardiovascular Diseases
(blood, epidemiology)
- Coronary Disease
(blood, epidemiology)
- Female
- Humans
- Insulin
(blood)
- Insulin Resistance
(physiology)
- Metabolic Syndrome
(blood, epidemiology)
- Odds Ratio
- Radioimmunoassay
- Socioeconomic Factors
- Testosterone
(blood)
- Treatment Outcome
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