Autoantibodies and the risk of cardiovascular events.
Abstract | OBJECTIVE: METHODS: We performed a population-based cohort study of all subjects who had a RF and/or ANA test performed between January 1, 1990, and January 1, 2000, and/or CCP test performed between September 1, 2003, and January 1, 2005, with followup until April 1, 2007. Outcomes were ascertained using diagnostic indices from complete medical records, including CV events [ myocardial infarction (MI), heart failure (HF), and peripheral vascular disease (PVD)] and mortality. Cox models were used to analyze the data. RESULTS: There were 6783 subjects with RF, 7852 with ANA, and 299 with CCP testing. Of these, 10.4%, 23.9%, and 14.7% were positive for RF, ANA, and CCP, respectively. Adjusting for age, sex, calendar year, comorbidity, and rheumatic disease, RF and ANA positivity were significant predictors of CV events [hazard ratio (HR) 1.24 and 1.26] and death (HR 1.43 and 1.18). Adjusting for age, CCP positivity was associated with CV events, but this association was not statistically significant (HR 3.1; 95% CI 0.8, 12.3). CONCLUSION: RF and ANA positivity are significant predictors of CV events and mortality in both those with and those without rheumatic diseases. These results support the role of immune dysregulation in the etiology of CV disease.
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Authors | Kimberly P Liang, Hilal Maradit Kremers, Cynthia S Crowson, Melissa R Snyder, Terry M Therneau, Veronique L Roger, Sherine E Gabriel |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 36
Issue 11
Pg. 2462-9
(Nov 2009)
ISSN: 0315-162X [Print] Canada |
PMID | 19833748
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antinuclear
- Autoantibodies
- Peptides, Cyclic
- cyclic citrullinated peptide
- Rheumatoid Factor
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Topics |
- Adult
- Antibodies, Antinuclear
(adverse effects, blood, immunology)
- Autoantibodies
(adverse effects, blood, immunology)
- Cardiovascular Diseases
(blood, immunology, mortality)
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Peptides, Cyclic
(adverse effects, blood, immunology)
- Predictive Value of Tests
- Rheumatoid Factor
(adverse effects, blood, immunology)
- Risk Factors
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