This study was purposed to investigate the expression of
annexin II in patients with
hematologic malignancies and its role in genesis and development of
hematologic malignancies. The expression levels of
annexin II in bone marrow cells from untreated 81 patients with acute
leukemia, 6 patients with MM and 20 patients with
iron deficiency anemia were detected by real-time PCR assay. The results showed that the expression of
annexin II mRNA significantly increased in M(3) patients as compared with others, the expression of
annexin II gene in groups M(5), MM, M(4) were higher than that of other groups except M(3) group, and there were no significant difference in expression of
annexin II gene between M(1) + M(2) groups and controls. It is concluded that the expression of
annexin II gene significantly increased in patients M(5), M(4), MM, who showed higher ratio of infiltration than other patients. It is inferred that the
annexin II participates in invasion and infiltration of
hematologic malignancies probably through enhancing the degradation of extracellular matrix by cells of
hematologic malignancies.