Increased inositol phosphoglycan P-type in the second trimester in pregnant women with type 2 and gestational diabetes mellitus.

Abstract

A progressive insulin resistant state develops throughout human pregnancy. Inositol phosphoglycan P-type (P-IPG), a second messenger of insulin, was reported to negatively correlate with the degree of insulin resistance in non-pregnant diabetic subjects. Urinary levels of P-IPG were assessed in insulin resistant states during pregnancy such as gestational diabetes mellitus (GDM, n=44) and type 2 diabetes mellitus (type 2 DM, n=25) and in 69 normal pregnant women. Urinary levels of P-IPG were higher in GDM than controls with a positive trend of release throughout normal pregnancy (P<0.01). P-IPG excretion was higher in diabetic (GDM and type 2 DM) than in healthy women in the second trimester (P<0.05). A higher P-IPG urinary excretion occurs during the second trimester in pregnant women with clinically evident insulin resistance with a positive association with poor glycemic control.

• Authors: Marco Scioscia, Khalid Gumaa, Luigi E Selvaggi, Charles H Rodeck, Thomas W Rademacher
• Journal: Journal of perinatal medicine (J Perinat Med) Vol. 37 Issue 5 Pg. 469-71 ( 2009) ISSN: 1619-3997 [Electronic] Germany
• PMID: 19492925 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Inositol Phosphates
• Polysaccharides
• inositol phosphate glycan

Topics

• Adult
• Birth Weight
• Blood Glucose (metabolism)
• Body Mass Index
• Case-Control Studies
• Diabetes Mellitus, Type 2 (blood, complications, pathology, urine)
• Diabetes, Gestational (blood, pathology, urine)
• Female
• Humans
• Infant, Newborn
• Inositol Phosphates (urine)
• Insulin Resistance (physiology)
• Pilot Projects
• Polysaccharides (urine)
• Pregnancy
• Pregnancy Outcome
• Pregnancy Trimester, Second
• Pregnancy in Diabetics (blood, pathology, urine)