Mammary tumorigenesis through LPA receptor signaling.

Abstract	Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors. In this issue of Cancer Cell, Liu et al. show that transgenic overexpression of ATX or LPA receptors leads to invasive and metastatic mammary cancer.
Authors	Jos Jonkers, Wouter H Moolenaar
Journal	Cancer cell (Cancer Cell) Vol. 15 Issue 6 Pg. 457-9 (Jun 02 2009) ISSN: 1878-3686 [Electronic] United States
PMID	19477423 (Publication Type: Comment, Journal Article)
Chemical References	Multienzyme Complexes Receptors, Lysophosphatidic Acid Phosphoric Diester Hydrolases Phosphodiesterase I alkylglycerophosphoethanolamine phosphodiesterase Pyrophosphatases
Topics	Animals Cell Transformation, Neoplastic (metabolism, pathology) Female Humans Lung Neoplasms (secondary) Lymphatic Metastasis Mammary Neoplasms, Experimental (metabolism, pathology) Mice Mice, Transgenic Multienzyme Complexes (genetics, metabolism) Neoplasm Invasiveness Phosphodiesterase I (genetics, metabolism) Phosphoric Diester Hydrolases Pyrophosphatases (genetics, metabolism) Receptors, Lysophosphatidic Acid (genetics, physiology) Signal Transduction (physiology)

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