Interleukin 17 production among patients with American cutaneous leishmaniasis.

Abstract

Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.

• Authors: Olívia Bacellar, Daniela Faria, Márcia Nascimento, Thiago M Cardoso, Kenneth J Gollob, Walderez O Dutra, Phillip Scott, Edgar M Carvalho
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 200 Issue 1 Pg. 75-8 (Jul 01 2009) ISSN: 0022-1899 [Print] United States
• PMID: 19476435 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-17

Topics

• Autoimmunity
• Humans
• Inflammation (immunology)
• Interleukin-17 (genetics)
• Leishmaniasis, Mucocutaneous (genetics, immunology)
• Lymphocyte Activation (genetics, immunology)
• Lymphocytes (immunology)
• Reference Values
• Th1 Cells (immunology)