Abstract | OBJECTIVES: To evaluate the role of computed tomography (CT) perfusion in detection of pancreatic necrosis and pancreatitis after endoscopic ultrasound-guided ethanol ablation of porcine pancreas and to correlate the evaluation with histopathology. METHODS: Under endoscopic ultrasound guidance, 0.9% saline (control) and ethanol at 60%, 80%, and 100% concentrations were injected into the pancreatic tails of 4 pigs. On day 4, dynamic perfusion CT of the pancreas was performed. Perfusion analysis and evaluation of enhancement characteristics were done and correlated with histopathology. RESULTS:
Ethanol injections at 80% and 100% concentrations resulted in focal necrosis surrounded by focal pancreatitis, whereas 60% ethanol injection caused severe focal pancreatitis with microscopic necrosis. The necrotic area revealed reduced blood flow, blood volume, permeability-surface area product, and increased mean transit time compared with pancreatitis and normal tissue (P < or = 0.001). In the control pig, no pancreatitis or necrosis was observed on perfusion images and histopathology. CONCLUSIONS:
|
Authors | Dushyant V Sahani, Nagaraj-Setty Holalkere, Avinash Kambadakone, Kai Matthes, Mari Mino-Kenudson, William R Brugge |
Journal | Pancreas
(Pancreas)
Vol. 38
Issue 7
Pg. 775-81
(Oct 2009)
ISSN: 1536-4828 [Electronic] United States |
PMID | 19465884
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Animals
- Disease Models, Animal
- Endosonography
- Ethanol
(administration & dosage)
- Female
- Image Enhancement
- Injections
- Male
- Necrosis
- Pancreas
(drug effects, pathology)
- Pancreatitis
(diagnosis, diagnostic imaging)
- Severity of Illness Index
- Swine
- Tomography, X-Ray Computed
(methods)
|